Catalog No.: PC-21679Not For Human Use, Lab Use Only.
Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA, binds to the IRE of SNCA mRNA with EC50 of 2.9 µM and Kd value of 1.8 uM.
Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA, binds to the IRE of SNCA mRNA with EC50 of 2.9 µM and Kd value of 1.8 uM.
Synucleozid-2.0 selectively binds to and stabilizes the A bulge and adjacent closed base pairs in the 5' UTR IRE of SNCA mRNA.
Synucleozid-2.0 blocks the translation process and reduces intracellular levels of α-synuclein.
Synucleozid-2.0 exerts cytoprotective effects against cytotoxicity induced by α-synuclein preformed fibrils.
