| Cat. No. |
Product Name |
Information |
| PC-62065 |
MRS2485
Aβ42 inhibitor
|
MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.. |
| PC-60881 |
Chicago Sky Blue 6B
MIF inhibitor, PrP ligand
|
A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry, also is the first small molecule prion protein (PrP) ligand capable of inhibiting Aβ binding. |
| PC-60873 |
BIOD303
α-synuclein modulator
|
BIOD303 is a novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
| PC-45445 |
ARN2966
APP expression modulator
|
ARN2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP). |
| PC-42798 |
TH-237A
Neuroprotective agent
|
TH-237A (meso-GS 164) is a brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity. |
| PC-45627 |
FPS-ZM1
RAGE inhibitor
|
FPS-ZM1 is a high-affinity RAGE-specific inhibitor with Ki of 25 nM, blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. |
| PC-28529 |
SBI-2771
Tau-LRP1 inhibitor
|
SBI-2771 is a small-molecule inhibitor of the Tau-LRP1 (low-density lipoprotein receptor-related protein 1) interaction with IC50 of 4.5 uM in LRP1-BD4-L57 TR-FRET assay, reduces tau uptake in H4 neuroglioma cells. |
| PC-28528 |
SBI-9635
Tau-LRP1 inhibitor
|
SBI-9635 is a small-molecule inhibitor of the Tau-LRP1 (low-density lipoprotein receptor-related protein 1) interaction with IC50 of 11 uM in LRP1-BD4-L57 TR-FRET assay, reduces tau uptake in H4 neuroglioma cells. |
| PC-27216 |
PBT434 mesylate
α-synuclein inhibitor
|
PBT434 mesylate is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease. |
| PC-27215 |
ACI-16664
Tau aggregation inhibitor
|
ACI-16664 is an orally available brain penetrant tau aggregation inhibitor with IC50 of 0.27 uM, selectively binds and destabilizes pathological β sheets in tau aggregates. |
| PC-26372 |
SBLR876
RAGE inhibitor
|
SBLR876 is a potent RAGE inhibitor, inhibits AGE-RAGE binding with an IC50 of 282.2 nM, blocks downstream NF-κB signaling. |
| PC-24359 |
OAB-14
Aβ modulator
|
OAB-14 is a bexaroten derivative that reduces the deposition of Aβ, promotes microglia phagocytosis and increasing IDE and NEP expression. |
