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Licochalcone B

Chemical Structure : Licochalcone B

CAS No.: 58749-23-8

Licochalcone B

Catalog No.: PC-23579Not For Human Use, Lab Use Only.

Licochalcone B is an extract from the root of Glycyrrhiza uralensis, inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduces metal-induced Aβ42 aggregation through chelating metal ions.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Licochalcone B is an extract from the root of Glycyrrhiza uralensis, inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduces metal-induced Aβ42 aggregation through chelating metal ions.
Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
Licochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway.
Licochalcone B inhibits growth and induces apoptosis of NSCLC cells.

Physicochemical Properties

M.Wt 286.28
Formula C16H14O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

References

1. Cao Y, et al. Nat Prod Res. 2018 Oct 22:1-4.

2. Jun-ichi Furusawa, et al. Int Immunopharmacol. 2009 Apr;9(4):499-507.

3. Ha-Na Oh, et al. Phytomedicine. 2019 Oct;63:153014.

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