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Cat. No. Product Name Information
PC-21685

SRI-42667

Tau-SH3 inhibitor

SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
PC-21679

Synucleozid-2.0

α-synuclein inhibitor

Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA.
PC-21401

DDQ

Aβ-Drp1 inhibitor

DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects.
PC-20803

MeSC-04

α-synuclein inhibitor

MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro.
PC-20458

CNB-001

CNB-001 is a pyrazole derivative of curcumin with neuroprotective properties, inhibits extracellular Aβ toxicity in hippocampal neurons with EC50 of 400 nM.
PC-38734

Senile plaques (SPs) probe BSB

Aβ-specific ligand

Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM).
PC-38480

TAE-1

Amyloid-beta modulator

TAE-1 is a sym-triazine-derived aggregation modulator, destabilizes Aβ1-42 assembly and inhibits amyloid-β fibril formation, also inhibits acetylcholinesterase (AChE) activity in SH-SY5Y neuronal cells.
PC-38408

ALI6

Aβ-LilrB2 inhibitor

ALI6 (Fluspirilene, Aβ-LilrB2 interaction inhibitor 6) is a small molecule Aβ-LilrB2 interaction inhibitor with Ki of 320 nM, blocks LilrB2 induced cell attachment and inhibit toxicity of Aβ.
PC-73339

Ro 90-7501

Aβ42 inhibitor

Ro 90-7501 is a prototypic inhibitor for Abeta42 (Aβ42) fibril formation, reduces Aβ42-induced cytotoxicity (EC50=2 uM), also enhances TLR3 and RLR agonist induced antiviral response.
PC-73121

anle145c

Amyloid aggregation inhibitor

anle145c is a small molecule inhibitor of amyloid aggregation and formation, inhibits human islet amyloid polypeptide (hIAPP)-induced death of INS-1E cells.
PC-35456

TRX-0237 Methylate

TRX-0237 Methylate (LMTX) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
PC-35455

TRX-0237

TRX-0237 Methylate (Hydromethylthionine, Methylene blue) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

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