| Cat. No. |
Product Name |
Information |
| PC-62066 |
MRS2481
Aβ inhibitor
|
MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity. |
| PC-62065 |
MRS2485
Aβ inhibitor
|
MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.. |
| PC-60873 |
BIOD303
α-synuclein modulator
|
BIOD303 is a novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
| PC-45445 |
ARN-2966
APP expression modulator
|
ARN-2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP). |
| PC-45627 |
FPS-ZM1
|
FPS-ZM1 is a high-affinity RAGE-specific inhibitor. |
| PC-22533 |
C05-05
α-synuclein imaging agent
|
C05-05 is a small molecule imaging agent for α-synuclein pathologies for in vivo optical visualization of α-synuclein inclusions and tracking of pathological α-synuclein propagation. |
| PC-22406 |
ROF2
Amyloid probe
|
ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays. |
| PC-21685 |
SRI-42667
Tau-SH3 inhibitor
|
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability. |
| PC-21679 |
Synucleozid-2.0
α-synuclein inhibitor
|
Synucleozid-2.0 is a drug-like small molecule that decreases α-synuclein levels by inhibiting ribosomes from assembling onto SNCA mRNA. |
| PC-21401 |
DDQ
Aβ-Drp1 inhibitor
|
DDQ is a small molecule inhibitor of binding sites of Amyloid beta (Aβ) and Drp1, reduces interaction between Aβ and Drp1, shows anti-aging effects. |
| PC-20803 |
MeSC-04
α-synuclein inhibitor
|
MeSC-04 is a potent α-Syn amyloid formation inhibitor, reduces the number and size of amyloid fibrils in vitro. |
| PC-38734 |
Senile plaques (SPs) probe BSB
Aβ-specific ligand
|
Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM). |
