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SEN1269

Chemical Structure : SEN1269

CAS No.: 956128-01-1

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SEN1269 (SEN-1269)

Catalog No.: PC-63233Not For Human Use, Lab Use Only.

SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM.
    SEN1269 produces a concentration-related blockade of Aβ(1-42) aggregation and protects neuronal cell lines exposed to Aβ(1-42).
    SEN1269 alleviates deficits in hippocampal LTP induced by Aβ(1-42) and cell-derived Aβ oligomers.
    SEN1269 reduces Aβ-induced neurotoxicity and shows neuroprotective in behavioural models of memory relevant to Aβ-induced neurodegeneration.

    Physicochemical Properties

    M.Wt 322.368
    Formula C18H18N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((5-(3-(dimethylamino)phenoxy)pyrimidin-2-yl)amino)phenol

    References

    1. Scopes DI, et al. Br J Pharmacol. 2012 Sep;167(2):383-92.

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