Chemical Structure : Leucomethylene blue mesylate
CAS No.: 1236208-20-0
Catalog No.: PC-35456Not For Human Use, Lab Use Only.
Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
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Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
Leucomethylene blue mesylate disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways.
Leucomethylene blue mesylate demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.
M.Wt | 379.493 | |
Formula | C17H21N3O3S2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
3,7-bis(dimethylamino)phenothiazin-5-ium methanesulfonate |
1. Harrington CR, et al. J Biol Chem. 2015 Apr 24;290(17):10862-75.
2. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12.
3. Seripa D, et al. Expert Rev Neurother. 2016;16(3):259-77.
4. Wilcock GK, et al. J Alzheimers Dis. 2018;61(1):435-457.
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