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Leucomethylene blue mesylate

Chemical Structure : Leucomethylene blue mesylate

CAS No.: 1236208-20-0

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine)

Catalog No.: PC-35456Not For Human Use, Lab Use Only.

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.

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Biological Activity

Leucomethylene blue mesylate (Trx0237, LMTX, Hydromethylthionine) is a Tau aggregation inhibitor (TAI) with Ki of 0.12 uM for intracellular TAI activity.
Leucomethylene blue mesylate disrupts paired helical filaments (PHFs) isolated from AD brain tissues at 0.16 uM, delays cellular senescence and enhances key mitochondrial biochemical pathways.
Leucomethylene blue mesylate demonstrates activities in clinical trials in Alzheimer's disease (AD) with drugs targeting β-amyloid accumulation in the brain.

Physicochemical Properties

M.Wt 379.493
Formula C17H21N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3,7-bis(dimethylamino)phenothiazin-5-ium methanesulfonate

References

1. Harrington CR, et al. J Biol Chem. 2015 Apr 24;290(17):10862-75.

2. Atamna H, et al. FASEB J. 2008 Mar;22(3):703-12.

3. Seripa D, et al. Expert Rev Neurother. 2016;16(3):259-77.

4. Wilcock GK, et al. J Alzheimers Dis. 2018;61(1):435-457.

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