| Cat. No. |
Product Name |
Information |
| PC-43143 |
PE859
Tau aggregation inhibitor
|
PE859 is a novel, orally active tau aggregation inhibitor that inhibits the heparin-induced aggregation of both 3RMBD and full length tau with IC50 of 0.81 uM and 2.23 uM, respectively. |
| PC-63233 |
SEN1269
Aβ aggregation inhibitor
|
SEN1269 is a potent Aβ aggregation inhibitor that binds to monomeric Aβ1-42 with Kd of 4.4 uM, protects neuronal cell lines against an Aβ1-42 insult with IC50 of 15 uM. |
| PC-63227 |
RU-505
Aβ42-fibrinogen inhibitor
|
RU-505 (RU505) is an effective inhibitor of the Aβ42-fibrinogen interaction with IC50 of 2.72 uM in FP assays. |
| PC-63202 |
TDI-2760
Aβ aggregation inhibitor
|
TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process. |
| PC-63196 |
BNC-1
Elk-1 activator
|
BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2. |
| PC-63133 |
GSK3039294
SAP inhibitor
|
GSK3039294 is an orally available small molecule inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils for the depletion of serum amyloid-P (SAP) component from the circulation, an orally bioavailable pro‐drug of miridesap. |
| PC-63132 |
Miridesap
SAP inhibitor
|
Miridesap (Ro 638695, GSK-2315698, CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils. |
| PC-62602 |
ALZ-801
Aβ inhibitor
|
ALZ-801 (Valiltramiprosate) is an orally available, valine-conjugated prodrug of tramiprosate, a small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor for the treatment of Alzheimer's disease. |
| PC-62381 |
RH01386
α-synuclein inhibitor
|
RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro. |
| PC-62194 |
Aβ polymerization stimulator O4
Aβ polymerization inducer
|
Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ). |
| PC-62066 |
MRS2481
Aβ inhibitor
|
MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity. |
| PC-62065 |
MRS2485
Aβ42 inhibitor
|
MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.. |
