| Cat. No. |
Product Name |
Information |
| PC-63132 |
Miridesap
SAP inhibitor
|
Miridesap (Ro 638695, GSK-2315698, CPHPC) is a competitive inhibitor of serum amyloid P component (SAP) binding to amyloid fibrils. |
| PC-62602 |
ALZ-801
Aβ inhibitor
|
ALZ-801 (Valiltramiprosate) is an orally available, valine-conjugated prodrug of tramiprosate, a small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor for the treatment of Alzheimer's disease. |
| PC-62381 |
RH01386
α-synuclein inhibitor
|
RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro. |
| PC-62194 |
Aβ polymerization stimulator O4
Aβ polymerization inducer
|
Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ). |
| PC-62066 |
MRS2481
Aβ inhibitor
|
MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity. |
| PC-62065 |
MRS2485
Aβ inhibitor
|
MRS 2485 is a potent, irreversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.. |
| PC-60881 |
Chicago Sky Blue 6B
MIF inhibitor, PrP ligand
|
A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry, also is the first small molecule prion protein (PrP) ligand capable of inhibiting Aβ binding. |
| PC-60873 |
BIOD303
α-synuclein modulator
|
BIOD303 is a novel conformational modulator of α-synuclein with EC50 of 105 uM, potentially outcompetes spermine in binding to α-synuclein. |
| PC-45445 |
ARN-2966
APP expression modulator
|
ARN-2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP). |
| PC-42798 |
TH-237A
Neuroprotective agent
|
TH-237A (meso-GS 164) is a brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity. |
| PC-45627 |
FPS-ZM1
RAGE inhibitor
|
FPS-ZM1 is a high-affinity RAGE-specific inhibitor with Ki of 25 nM, blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo. |
| PC-23221 |
TZ095
Aβ fluorescent probe
|
TZ095 is a coumarin-based Aβ fluorescent probe for precise Aβ detection, exhibits remarkable affinity with Aβ aggregates (Kd = 81.54 nM for oligomers; Kd = 66.70 nM for fibril) and substantial fluorescence enhancement (F/F0 = 44). |
