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TH-237A

Chemical Structure : TH-237A

CAS No.: 935467-97-3

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TH-237A (TH237A, meso-GS 164)

Catalog No.: PC-42798Not For Human Use, Lab Use Only.

TH-237A (meso-GS 164) is a brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity.

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10 mg $128 In stock
25 mg $218 In stock
50 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

TH-237A (meso-GS 164) is a brain penetrant neuroprotective agent that protects neurons against β-amyloid (Aβ) induced neurotoxicity.
TH-237A increases neuronal survival in the presence of the Aβ peptides in rat isolated neuronal culture with EC50 of 5 nM.

Physicochemical Properties

M.Wt 333.3293
Formula C18H17F2NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol, 3,5-bis(4-fluorophenyl)-, (3R,5S)-rel-

References

1. Kelly E. Desino. Improving Blood Brain Barrier Permeation of Small Molecules Exhibiting Chemotherapeutic and Neuroprotective Effects.

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