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RH01386

Chemical Structure : RH01386

CAS No.: 301177-36-6

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RH01386 (ZPD-2, RH 01386)

Catalog No.: PC-62381Not For Human Use, Lab Use Only.

RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro.

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25 mg $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro.
RH01386 (ZPD-2) increases the survival of human primary β cells and rodent β cell lines subjected to ER stressors including palmitate; also restores ER stress-impaired glucose-stimulated insulin secretion responses.
ZPD-2 inhibits the aggregation of wild-type (WT) α-Syn, the A30P and H50Q familial mutants, being active against the seeded polymerization of different α-Syn strains.
ZPD-2 prevents the spreading of α-Syn seeds in protein misfolding cyclic amplification assays.
ZPD-2 is active against different α-Syn strains and blocks their seeded polymerization.
ZPD-2 reduces the number of α-Syn inclusions and decreases synuclein-induced DA neurons degeneration in two different PD Caenorhabditis elegans models that express α-Syn either in muscle or in dopaminergic (DA) neurons.

Physicochemical Properties

M.Wt 424.398
Formula C18H15F3N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-cyclohexyl-2-((2-nitro-4-(trifluoromethyl)phenyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

References

1. Tran K, et al. ACS Chem Biol. 2014 Dec 19;9(12):2796-806.
2. Pena-Diaz S., et al. Front. Mol. Neurosci. 2019;12:306.

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