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MRS2481

Chemical Structure : MRS2481

CAS No.: 859724-30-4

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MRS2481 (MRS-2481)

Catalog No.: PC-62066Not For Human Use, Lab Use Only.

MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    MRS 2481 is a potent, reversible Aβ42 neurotoxicity inhibitor with ID50 of 500 nM, potently blocks the Aβ calcium channel and protects neurons from Aβ toxicity.
    MRS 2481 also is a potent inhibitor of TNFα-induced phosphorylation and proteosomal destruction of IκBα, inhibits both NFκB and AP-1 signaling on the IL-8 promoter (IC50=1.8 uM).
    MRS 2481 blocks TNFα-activated phosphorylation of JNK, the c-JUN kinase.

    Physicochemical Properties

    M.Wt 420.391
    Formula C22H30BrNO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(8-((2-phenylpropanoyl)oxy)octyl)pyridin-1-ium bromide

    References

    1. Diaz JC, et al. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3348-53.

    2. Tchilibon S, et al. Biochem Pharmacol. 2005 Aug 1;70(3):381-93.

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