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Chemical Structure : Aβ polymerization stimulator O4
Catalog No.: PC-62194Not For Human Use, Lab Use Only.
Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
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Aβ polymerization stimulator O4 is an orcein-related small molecule can drive polymerization of amyloid-β (Aβ).
Aβ polymerization stimulator O4 directly binds to hydrophobic amino acid residues in Aβ peptides and stabilizes the self-assembly of seeding-competent, β-sheet-rich protofibrils and fibrils, efficiently decreases the concentration of small, toxic Aβ oligomers in complex, heterogeneous aggregation reactions.
Aβ polymerization stimulator O4 suppresses inhibition of long-term potentiation by Aβ oligomers in hippocampal brain slices.
| M.Wt | 429.384 | |
| Formula | C24H15NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bieschke J, et al. Nat Chem Biol. 2011 Nov 20;8(1):93-101.
2. Sun Y, et al. J Phys Chem B. 2015 Feb 19;119(7):2786-94.
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