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ARN-2966

Chemical Structure : ARN-2966

CAS No.: 102212-26-0

ARN-2966 (ARN2966;ARN 2966)

Catalog No.: PC-45445Not For Human Use, Lab Use Only.

ARN-2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ARN-2966 is a potent, BBB penetrant post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP); reduces expression of APP with resultant lower production of Aβ; improves the memory and reduces Aβ in AD transgenic mice; orally active.

Physicochemical Properties

M.Wt 200.2365
Formula C12H12N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 43.4 mg/mL

Chemical Name/SMILES

Phenol, 2-[(2-pyridinylmethyl)amino]-

References

1. Ayodeji Asuni, et al. DOI: http://dx.doi.org/10.1016/j.jalz.2013.08.025

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