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BNC-1

Chemical Structure : BNC-1

CAS No.: 96335-59-0

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BNC-1 (BNC1)

Catalog No.: PC-63196Not For Human Use, Lab Use Only.

BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BNC-1 is a small molecule modulator of Amyloid pathology by promoting phosphorylation and activation of Elk-1, a transcriptional repressor of presenilin-1 but not presenilin-2.
    BNC-1 increases levels of synaptophysin and synapsin, markers of synaptic integrity, but does not adversely impact presenilin-2 or processing of Notch-1.
    BNC-1 significantly decreases amyloid burden and improves markers of synaptic integrity in a well-established mouse model of amyloid deposition.

    Physicochemical Properties

    M.Wt 282.299
    Formula C16H14N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Methyl 2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine-1-carboxylate

    References

    1. Lovell MA, et al. J Alzheimers Dis. 2016 May 4;53(1):273-87.

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