ELN484228 is a small molecule binder of α-synuclein that shows protective effect in cellular models of αSyn-mediated vesicular dysfunction.
ELN484228 rescues α-synuclein-induced disruption of vesicle trafficking and dopaminergic neuronal loss and neurite retraction most likely by reducing the amount of α-synuclein targeted to sites of vesicle mobilization such as the synapse in neurons or the site of bead engulfment in microglial cells.
ELN484228 shows potential therapeutic strategy for Parkinson's disease.
Physicochemical Properties
M.Wt
251.28
Formula
C12H10FNO2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-Fluorophenyl)-benzenesulfonamide
References
1. Tóth G, et al. PLoS One. 2014 Feb 14;9(2):e87133.
