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YX-A-1

Chemical Structure : YX-A-1

CAS No.: 1381156-50-8

YX-A-1 (Amyloid modulator)

Catalog No.: PC-38108Not For Human Use, Lab Use Only.

YX-A-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically enhances amyloid formation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YX-A-1 is a small-molecule modulator of human islet amyloid polypeptide (hIAPP) assembly, specifically enhances amyloid formation.
    YX-A-1 accelerates wt hIAPP assembly, even when added in substoichiometric concentration ratios (e.g. at a peptide:YX-A-1 molar ratio of 1:0.5 the t50 is reduced ~1.5-fold).
    YX-A-1 is a useful chemical tools to study hIAPP aggregation.

    Physicochemical Properties

    M.Wt 446.526
    Formula C26H27FN4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(2-(cyclohexanecarboxamido)ethyl)-N-(2-fluorophenyl)-2-phenylpyrimidine-5-carboxamide

    References

    1. Yong Xu, et al. Nat Commun. 2022 Feb 24;13(1):1040.

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