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NPT200-11

Chemical Structure : NPT200-11

CAS No.: 1802518-63-3

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NPT200-11 ((Rac)-Minzasolmin, (Rac)-UCB0599)

Catalog No.: PC-35764Not For Human Use, Lab Use Only.

NPT200-11 is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.

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5 mg $388 In stock
10 mg $558 In stock
25 mg $898 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NPT200-11 ((Rac)-Minzasolmin, (Rac)-UCB0599) is an orally bioavailable and brain penetrating alpha-synuclein (ASYN) misfolding and aggregation inhibitor.
NPT200-11 reduced retinal alpha-synuclein pathology in cortex, reduced associated neuroinflammation (astrogliosis), normalized striatal levels of the dopamine transporter (DAT) and improved motor function in animal model of Parkinson's disease.

Physicochemical Properties

M.Wt 425.60
Formula C23H31N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-(1H-indol-3-yl)hexan-2-yl)-2-(4-methylpiperazin-1-yl)thiazole-5-carboxamide

References

1. Price DL, et al. Sci Rep. 2018 Nov 1;8(1):16165.

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