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FPS-ZM1

Chemical Structure : FPS-ZM1

CAS No.: 945714-67-0

FPS-ZM1 (RAGE inhibitor)

Catalog No.: PC-45627Not For Human Use, Lab Use Only.

FPS-ZM1 is a high-affinity RAGE-specific inhibitor with Ki of 25 nM, blocks Aβ binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FPS-ZM1 is a high-affinity RAGE-specific inhibitor with Ki of 25 nM, blocks binding to the V domain of RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo.

Physicochemical Properties

M.Wt 327.8478
Formula C20H22ClNO
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, 4-chloro-N-cyclohexyl-N-(phenylmethyl)-

References

1. Deane R, et al. J Clin Invest. 2012 Apr;122(4):1377-92.

2. Hong Y, et al. Neurochem Res. 2016 May;41(5):1192-9.

3. Kwak T, et al. Oncogene. 2017 Mar;36(11):1559-1572.

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