Chemical Structure : ROF2
CAS No.:
2885163-10-8
ROF2
(ROF-2)
Catalog No.: PC-22406Not For Human Use, Lab Use Only.
ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.
ROF2 dispalys superior sensing capability in monitoring, detecting, and distinguishing amyloid aggregates of different sequences (Amyloid-β, human islet amyloid polypeptide, or human calcitonin) and sizes (monomers, oligomers, or fibrils), compared with Thioflavin T (ThT).
ROF2 exhibits the aggregation- and concentration-dependent emissive property for amyloid detection.
ROF2 (0.2 uM) is sufficiently effective in detecting amyloid aggregates, induces significant fluorescence upon binding to amyloid aggregates.
Physicochemical Properties
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M.Wt
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485.60
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Formula
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C29H27NO4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(Z)-4-(4-(methylsulfonyl)phenyl)-3-phenyl-5-(2-(piperidin-1-yl)benzylidene)furan-2(5H)-one
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References
1. Tang Y, et al. Small. 2024 May 15:e2400879.
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