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Chemical Structure : ROF2
Catalog No.: PC-22406Not For Human Use, Lab Use Only.
ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.
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ROF2 is an aggregation-induced emission (AIE) small molecule, functionalities as an amyloid probe and a screening tool for amyloid inhibitors using different biophysical, cellular, and worm assays.
ROF2 dispalys superior sensing capability in monitoring, detecting, and distinguishing amyloid aggregates of different sequences (Amyloid-β, human islet amyloid polypeptide, or human calcitonin) and sizes (monomers, oligomers, or fibrils), compared with Thioflavin T (ThT).
ROF2 exhibits the aggregation- and concentration-dependent emissive property for amyloid detection.
ROF2 (0.2 uM) is sufficiently effective in detecting amyloid aggregates, induces significant fluorescence upon binding to amyloid aggregates.
| M.Wt | 485.60 | |
| Formula | C29H27NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang Y, et al. Small. 2024 May 15:e2400879.
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