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Chemical Structure : SRI-42667
Catalog No.: PC-21685Not For Human Use, Lab Use Only.
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
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SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
SRI-42667 prevents Aβ-induced membrane trafficking dysfunction in the MTT assay and Aβ-induced neurite degeneration in the MAP2 assay.
SRI-42667 inhibits endogenous Tau-Fyn interaction at both 3 uM and 15 uM in primary neurons, does not lower Tau or Fyn levels in neurons.
SRI-42667 binds Tau (ITC KD=11.9 uM) but not FynSH3, does not inhibit Fyn or any of the 97 kinases in the DiscoverX KINOMEscan™.
SRI-42667 is a selective Tau-SH3 interaction inhibitor, does not broadly inhibit all Tau protein-protein interactions.
SRI-42667 ameliorates Aβ-induced neurite degeneration and network hyperexcitability.
| M.Wt | 336.36 | |
| Formula | C17H16N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jonathan R Roth, et al. Neurotherapeutics. 2023 Dec 19;21(1):e00291.
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