Chemical Structure : SRI-42667
CAS No.:
3024624-72-1
SRI-42667
(SRI 42667)
Catalog No.: PC-21685Not For Human Use, Lab Use Only.
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
SRI-42667 prevents Aβ-induced membrane trafficking dysfunction in the MTT assay and Aβ-induced neurite degeneration in the MAP2 assay.
SRI-42667 inhibits endogenous Tau-Fyn interaction at both 3 uM and 15 uM in primary neurons, does not lower Tau or Fyn levels in neurons.
SRI-42667 binds Tau (ITC KD=11.9 uM) but not FynSH3, does not inhibit Fyn or any of the 97 kinases in the DiscoverX KINOMEscan™.
SRI-42667 is a selective Tau-SH3 interaction inhibitor, does not broadly inhibit all Tau protein-protein interactions.
SRI-42667 ameliorates Aβ-induced neurite degeneration and network hyperexcitability.
Physicochemical Properties
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M.Wt
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336.36
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Formula
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C17H16N6O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-N-(5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)acetamide
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References
1. Jonathan R Roth, et al. Neurotherapeutics. 2023 Dec 19;21(1):e00291.
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