Catalog No.: PC-21685Not For Human Use, Lab Use Only.
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
SRI-42667 is a selective small-molecule Tau-SH3 interaction inhibitor with IC50 of 0.91 uM (Tau-FynSH3 interaction), prevents amyloid-β toxicity and network hyperexcitability.
SRI-42667 prevents Aβ-induced membrane trafficking dysfunction in the MTT assay and Aβ-induced neurite degeneration in the MAP2 assay.
SRI-42667 inhibits endogenous Tau-Fyn interaction at both 3 uM and 15 uM in primary neurons, does not lower Tau or Fyn levels in neurons.
SRI-42667 binds Tau (ITC KD=11.9 uM) but not FynSH3, does not inhibit Fyn or any of the 97 kinases in the DiscoverX KINOMEscan™.
SRI-42667 is a selective Tau-SH3 interaction inhibitor, does not broadly inhibit all Tau protein-protein interactions.
SRI-42667 ameliorates Aβ-induced neurite degeneration and network hyperexcitability.
