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TZ095

Chemical Structure : TZ095

CAS No.: 2972464-50-7

TZ095 (TZ-095)

Catalog No.: PC-23221Not For Human Use, Lab Use Only.

TZ095 is a coumarin-based Aβ fluorescent probe for precise Aβ detection, exhibits remarkable affinity with Aβ aggregates (Kd = 81.54 nM for oligomers; Kd = 66.70 nM for fibril) and substantial fluorescence enhancement (F/F0 = 44).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TZ095 is a coumarin-based Aβ fluorescent probe for precise Aβ detection, exhibits remarkable affinity with Aβ aggregates (Kd = 81.54 nM for oligomers; Kd = 66.70 nM for fibril) and substantial fluorescence enhancement (F/F0 = 44).

Physicochemical Properties

M.Wt 316.36
Formula C20H16N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-7-(4-(dimethylamino)styryl)-2-oxo-2H-chromene-3-carbonitrile

References

1. You H, et al. Eur J Med Chem. 2024 Nov 15;278:116800.

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