Catalog No.: PC-28069Not For Human Use, Lab Use Only.
APP degrader 0152 (Compound 0152) is a potent, CAPRIN1-dependent molecule glue degrader of amyloid precursor protein (APP), effectively reduces intracellular APP and extracellular Aβ42 without neuronal toxicity, effectively lowers Aβ42 secretion with IC50 of 0.9 uM in AG27606 neurons.
APP degrader 0152 (Compound 0152) is a potent, CAPRIN1-dependent molecule glue degrader of amyloid precursor protein (APP), effectively reduces intracellular APP and extracellular Aβ42 without neuronal toxicity, effectively lowers Aβ42 secretion with IC50 of 0.9 uM in AG27606 neurons.
Compound 0152 stabilizes the CAPRIN1‐APP interaction, consistent with a molecular glue mechanism.
Compound 0152 directs APP to lysosomes via CAPRIN1, induces lysosomal degradation of APP in AD iPSC-Ns.
Compound 0152 significantly reduces APP/Aβ42 accumulation in AD iPSC‐derived organoids.
Compound 0152 (100 mg/kg, IP) reduces amyloid burden in 5xFAD mice.
