Catalog No.: PC-38734Not For Human Use, Lab Use Only.
Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM).
Senile plaques (SPs) probe BSB is a chemical probe that can detect accumulation of Aβ in senile plaques (SPs) in vivo, exhibits high binding affinity for Aβ aggregates in vitro (Ki=0.4 uM).
BSB specifically labels SPs in postmortem AD brain sections with excellent fluorescent properties (λab = 340 nm; λem = 520 nm) and lipophilicity.
BSB effectively labels Aβ aggregates in vivo.
BSB shows potential as an antemortem diagnostic for Alzheimer's disease (AD).
Physicochemical Properties
M.Wt
481.298
Formula
C24H17BrO6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene
References
1. D M Skovronsky, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7609-14.
