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Synucleozid hydrochloride

Chemical Structure : Synucleozid hydrochloride

CAS No.: 2741856-68-6

Synucleozid hydrochloride (NSC 377363 Hcl)

Catalog No.: PC-38593Not For Human Use, Lab Use Only.

Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.

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Biological Activity

Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.
Synucleozid decreases 2-AP emission with an EC50 of 2.7 uM.
Synucleozid binds and stabilizes the SNCA IRE in cells at a specific structural element.
Synucleozid selectively reduces α-synuclein protein levels by decreasing the amount of SNCA mRNA loaded into polysomes, mechanistically providing a cytoprotective effect in cells.

Physicochemical Properties

M.Wt 404.902
Formula C22H21ClN6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Indole-6-carboximidamide, 2-[4-[[4-(aminoiminomethyl)phenyl]amino]phenyl]-, hydrochloride (1:1)

References

1. Zhang P, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.

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