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A-285222

Chemical Structure : A-285222

CAS No.: 245747-71-1

A-285222 (A-285)

Catalog No.: PC-26147Not For Human Use, Lab Use Only.

A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP) and selective nuclear factor of activated T cells (NFAT) inhibitor, inhibits PBMC proliferation stimulated by concanavalin A with IC50 of 146 nM, inhibits IL-2 synthesis in human blood with IC50 of 182 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP) and selective nuclear factor of activated T cells (NFAT) inhibitor, inhibits PBMC proliferation stimulated by concanavalin A with IC50 of 146 nM, inhibits IL-2 synthesis in human blood with IC50 of 182 nM.

Physicochemical Properties

M.Wt 416.28
Formula C17H10F6N4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-(5-(difluoromethoxy)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide

References

1. Bîrsan T, et al. Transpl Int. 2004 Mar;17(3):145-50.

2. Djuric SW, et al. J Med Chem. 2000 Aug 10;43(16):2975-81.

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