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Chemical Structure : A-412997 dihydrochloride
Catalog No.: PC-60614Not For Human Use, Lab Use Only.
A-412997 is a potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively.
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A-412997 is a potent, selective dopamine D4 receptor agonist with Ki of 12.1 and 7.9 nM for rat and human D4 receptors, respectively.
A-412997 displays excellent selectivity profile for other dopamine receptors or a panel of 70 different receptors and channels (Ki>1 uM).
A-412997 fully activates rat D4 receptor at 28.4 nM, does not activate rat dopamine D2L.
A-412997 induces penile erection in a conscious rat model with comparable efficacy as the nonselective D2-like agonist, apomorphine.
A-412997 also improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rats.
| M.Wt | 382.33 | |
| Formula | C19H23N3O.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Moreland RB, et al. Pharmacol Biochem Behav. 2005 Sep;82(1):140-7.
2. Browman KE, et al. Pharmacol Biochem Behav. 2005 Sep;82(1):148-55.
3. Woolley ML, et al. Behav Pharmacol. 2008 Dec;19(8):765-76.
4. Tomlinson A, et al. Eur Neuropsychopharmacol. 2015 Apr;25(4):454-67.
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