A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases.
A-443654 inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM.
A-443654 inhibits tumor growth in vivo, and is more potent and more selective than A-674563.
