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Chemical Structure : A-443654
CAS No.: 552325-16-3
Catalog No.: PC-42579Not For Human Use, Lab Use Only.
A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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A-443654 is a potent and selective Akt inhibitor with Ki of 0.16 nM for Akt1.
A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells, displays 40-fold selectivity over PKA, and CMGC family kinases.
A-443654 inhibits Akt-dependent signal transduction, inhibits proliferation of MiaPaCa-2 cells with EC50 of 0.1 uM.
A-443654 inhibits tumor growth in vivo, and is more potent and more selective than A-674563.
| M.Wt | 397.4723 | |
| Formula | C24H23N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Indole-3-ethanamine, .alpha.-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (.alpha.S)- |
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1. Luo Y, et al. Mol Cancer Ther. 2005 Jun;4(6):977-86.
2. Han EK, et al. Oncogene. 2007 Aug 16;26(38):5655-61.
3. Shi Y, et al. Neoplasia. 2005 Nov;7(11):992-1000.
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