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Chemical Structure : A-769662
CAS No.: 844499-71-4
Catalog No.: PC-45830Not For Human Use, Lab Use Only.
A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 50 mg | $200 | In stock | |
| 100 mg | $360 | In stock |
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A-769662 is a small molecule AMPK activator that directly stimulates partially purified rat liver AMPK (EC50=0.8 uM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50=3.2 uM).
A-769662 decreases hepatic expression of PEPCK, G6Pase, and FAS, lowered plasma glucose by 40%, reduces body weight gain and significantly decreases both plasma and liver triglyceride levels in ob/ob mice (30 mg/kg b.i.d.)。
A-769662 also directly inhibits Na(+)-K(+)-ATPase, decreases the sodium pump cell surface abundance in L6 skeletal muscle cells.
| M.Wt | 360.3859 | |
| Formula | C20H12N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 24 mg/mL |
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| Chemical Name/SMILES |
Thieno[2,3-b]pyridine-5-carbonitrile, 6,7-dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo- |
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1. Cool B, et al. Cell Metab. 2006 Jun;3(6):403-16.
2. Göransson O, et al. J Biol Chem. 2007 Nov 9;282(45):32549-60.
3. Benziane B, et al. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1554-66.
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