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A-804598

Chemical Structure : A-804598

CAS No.: 1125758-85-1

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A-804598 (A 804598, A804598)

Catalog No.: PC-42169Not For Human Use, Lab Use Only.

A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively.

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25 mg $138 In stock
50 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A-804598 is a potent, selective and competitive P2X7 receptor antagonist with IC50 of 10, 9 , and 11 nM for rat, mouse, and human P2X7, respectively.
A-804598 also potently blocks agonist stimulated release of IL-1beta and Yo-Pro uptake from differentiated THP-1 cells.
A-804598 partially attenuates footshock increased IL-1β and CD14 mRNA in the paraventricular nucleus in rats (25 mg/kg).

Physicochemical Properties

M.Wt 315.3718
Formula C19H17N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 32 mg/mL
Chemical Name/SMILES

Guanidine, N-cyano-N''-[(1S)-1-phenylethyl]-N'-5-quinolinyl-

References

1. Donnelly-Roberts DL, et al. Neuropharmacology. 2009 Jan;56(1):223-9.

2. Catanzaro JM, et al. Behav Pharmacol. 2014 Sep;25(5-6):582-98.

3. Ziff J, et al. ACS Chem Neurosci. 2016 Apr 20;7(4):498-504.

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