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Chemical Structure : A-836339
CAS No.: 959746-77-1
Catalog No.: PC-43187Not For Human Use, Lab Use Only.
A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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A-836339 (A836339) is a potent and selective cannabinoid CB2 receptor agonist with Ki of 0.64 and 0.76 nM for human and rat CB2 receptors, displays 425- and 189-fold selectivity over CB1 receptor, respectively.
A-836339 exhibits full agonist efficacy (Emax=102%) with high potency (EC50=1.6 nM), greater potency than other CB2-selective ligands including JWH-015 and GW-842166X.
A-836339 exhibits a potent CB2 receptor-mediated antihyperalgesic effect in various animal pain models.
A-836339 also demonstrates efficacies in the chronic constrain injury (CCI) model of neuropathic pain.
| M.Wt | 310.4548 | |
| Formula | C16H26N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 12 mg/mL |
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| Chemical Name/SMILES |
Cyclopropanecarboxamide, N-[3-(2-methoxyethyl)-4,5-dimethyl-2(3H)-thiazolylidene]-2,2,3,3-tetramethyl-, [N(Z)]- |
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1. Yao BB, et al. J Pharmacol Exp Ther. 2009 Jan;328(1):141-51.
2. McGaraughty S, et al. Neuroscience. 2009 Feb 18;158(4):1652-61.
3. Hsieh GC, et al. Br J Pharmacol. 2011 Jan;162(2):428-40.
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