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Chemical Structure : A-939572
CAS No.: 1032229-33-6
Catalog No.: PC-45850Not For Human Use, Lab Use Only.
A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.
A-939572 shows excellent selectivity and no significant hERG channel blockade activity (IC50>100 uM).
A-939572 prevents the diet-induced reduction of hepatic FAAH activity, normalizes hepatic AEA levels, and improves insulin sensitivity in HFD-fed mice.
A-939572 synergistically inhibits tumor growth in vitro and in vivo in combination with temsirolimus.
| M.Wt | 387.86 | |
| Formula | C20H22ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 56 mg/mL |
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| Chemical Name/SMILES |
1-Piperidinecarboxamide, 4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]- |
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1. Xin Z, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302.
2. von Roemeling CA, et al. Clin Cancer Res. 2013 May 1;19(9):2368-80.
3. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18832-7.
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