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A-939572

Chemical Structure : A-939572

CAS No.: 1032229-33-6

A-939572 (A939572)

Catalog No.: PC-45850Not For Human Use, Lab Use Only.

A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.

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Purity & Documentation Purity: 99.48% (HPLC) Select Batch:

Biological Activity

A-939572 is a potent, specific and orally bioavailable SCD1 inhibitor with IC50 of <4 nM and 37 nM for rSCD1 and hSCD1, respectively.
A-939572 shows excellent selectivity and no significant hERG channel blockade activity (IC50>100 uM).
A-939572 prevents the diet-induced reduction of hepatic FAAH activity, normalizes hepatic AEA levels, and improves insulin sensitivity in HFD-fed mice.
A-939572 synergistically inhibits tumor growth in vitro and in vivo in combination with temsirolimus.

Physicochemical Properties

M.Wt 387.86
Formula C20H22ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 56 mg/mL

Chemical Name/SMILES

1-Piperidinecarboxamide, 4-(2-chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-

References

1. Xin Z, et al. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4298-302.

2. von Roemeling CA, et al. Clin Cancer Res. 2013 May 1;19(9):2368-80.

3. Liu J, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18832-7.

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