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A4250

Chemical Structure : A4250

CAS No.: 501692-44-0

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A4250 (A-4250;Odevixibat;AZD 8294)

Catalog No.: PC-63453Not For Human Use, Lab Use Only.

A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A4250 (AZD 8294, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH.

    Physicochemical Properties

    M.Wt 740.931
    Formula C37H48N4O8S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Butanoic acid, 2-[[(2R)-[[[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino](4-hydroxyphenyl)acetyl]amino]-, (2S)- (9CI)

    References

    1. Graffner H, et al. Aliment Pharmacol Ther. 2016 Jan;43(2):303-10.

    2. Baghdasaryan A, et al. J Hepatol. 2016 Mar;64(3):674-81.

    3. Al-Dury S, et al. Sci Rep. 2018 Apr 27;8(1):6658.

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