Odevixibat (A4250) | ASBT inhibitor | Probechem Biochemicals

Chemical Structure : A4250

CAS No.: 501692-44-0

A4250 (A-4250, Odevixibat, AZD 8294)

Catalog No.: PC-63453Not For Human Use, Lab Use Only.

A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH..

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$358	In stock
50 mg	$588	In stock
100 mg		Get quote

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Biological Activity

A4250 (AZD 8294, Odevixibat) is a selective small molecule inhibitor of apical sodium-dependent bile acid transporter (ASBT, ileal bile acid transporter (IBAT) and SLC10A2).
A4250 (AZD 8294, Odevixibat) showed significant improvement of bile acid-associated hepatobiliary injury in MDR2 (ABCB4) knock-out mice, an established animal model of cholestatic liver disease

Physicochemical Properties

M.Wt	740.931
Formula	C37H48N4O8S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 2-[[(2R)-[[[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino](4-hydroxyphenyl)acetyl]amino]-, (2S)- (9CI)

References

1. Graffner H, et al. Aliment Pharmacol Ther. 2016 Jan;43(2):303-10.

2. Baghdasaryan A, et al. J Hepatol. 2016 Mar;64(3):674-81.

3. Al-Dury S, et al. Sci Rep. 2018 Apr 27;8(1):6658.

A4250 (A-4250, Odevixibat, AZD 8294)

Biological Activity

Physicochemical Properties

References

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