A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo. A779 inhibited antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral medulla. A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II). A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum.
Physicochemical Properties
M.Wt
872.97
Formula
C39H60N12O11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-L-Isoleucine-7-D-alanine-1-7-angiotensin II
References
1. Santos RA, et al. Brain Res Bull. 1994;35(4):293-8.
