| Cat. No. |
Product Name |
Information |
| PC-20515 |
Sparsentan
Dual AT-II and ETA antagonist
|
Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively. |
| PC-49657 |
Forasartan
AT1 receptor inhibitor
|
Forasartan (SC-52458) is a potent, specific, competitive and reversible angiotensin II receptor (AT1 receptor) antagonist with binding Ki value of 2.9 nM. |
| PC-73402 |
Azilsartan mopivabil
AT2R antagonist
|
Azilsartan mopivabil is a potent, selective angiotensin II receptor (AT2R) antagonist, with potential for hypertension, chronic heart failure and diabetic nephropathy. |
| PC-73401 |
Azilsartan mepixetil
AT2R antagonist
|
Azilsartan mepixetil is a potent, selective angiotensin II receptor antagonist, with potential for hypertension, chronic heart failure and diabetic nephropathy. |
| PC-72732 |
DCP1-3
AT1R allosteric modulator
|
DCP1-3 is a novel allosteric ligand of the angiotensin receptor AT1R, displays NAM potency on AngIV with IC50 of 0.29 uM. |
| PC-43383 |
EMA401
AT2R inhibitor
|
EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM. |
| PC-44124 |
Azilsartan
AT1 inhibitor
|
Azilsartan (TAK-536) is a specific and potent angiotensin II type 1 receptor (AT1) antagonist with IC50 of 2.6 nM, used in the treatment of adults with essential hypertension. |
| PC-45316 |
Losartan
AT1 inhibitor, PAX8 inhibitor
|
Losartan (DuP-753) is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist (IC50=20 nM) for treatment of high blood pressure (hypertension), also inhibits PAX8 expression and function. |
| PC-22028 |
BIO101
MasR agonist
|
BIO101 (20-hydroxyecdysone, Crustecdysone) is a small molecule agonist of Mas receptor (MasR), has anti-inflammatory, anti-fibrotic and cardioprotective properties, shows potential treatment for respiratory failure in COVID-19. |
| PC-21225 |
AVE-0991
Angiotensin-(1-7) agonist
|
AVE 0991 is a potent, selective nonpeptide and orally active angiotensin-(1-7) receptor Mas agonist, displaces the binding of 125I-Ang-(1-7) in Mas-transfected monkey kidney cells (COS) cells with IC50 of 47.5 nM. |
| PC-21224 |
A779
Angiotensin-(1-7) inhibitor
|
A779 is a potent, selective antagonist of angiotensin-(1-7) receptor Mas, blocks the antidiuretic effect of Ang-(1-7) in vivo. |
| PC-35877 |
TD-0212
|
TD-0212 (TD0212) is a potent, orally efficacious, dual AT1 antagonist/Neprilysin (NEP) inhibitor with pKi of 8.9 (AT1) and pIC50 of 9.2 (NEP). |
