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Chemical Structure : EMA401
CAS No.: 1316755-16-4
Catalog No.: PC-43383Not For Human Use, Lab Use Only.
EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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EMA401 (Olodanrigan) is a potent, highly selective angiotensin II type 2 receptor (AT2R) antagonist, inhibits capsaicin responses in cultured neurons of human and rat DRG with IC50 of 10 nM.
EMA401 is a novel peripherally-restricted analgesic, may act on paracrine/autocrine mechanisms at peripheral nerve terminals, or intracrine mechanisms, to reduce neuropathic pain signalling in AngII/NGF/TRPV1-convergent pathways.
| M.Wt | 507.5764 | |
| Formula | C32H29NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
3-Isoquinolinecarboxylic acid, 2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-, (3S)- |
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1. Anand U, et al. Eur J Pain. 2013 Aug;17(7):1012-26.
2. Smith MT, et al. Pain Med. 2013 May;14(5):692-705.
3. Rice ASC, et al. Lancet. 2014 May 10;383(9929):1637-1647.
4. Anand U, et al. Mol Pain. 2015 Jun 26;11:38.
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