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Chemical Structure : Sparsentan
CAS No.: 254740-64-2
Catalog No.: PC-20515Not For Human Use, Lab Use Only.
Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.
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|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
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Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.
Sparsentan dose dependently antagonizes the angiotensin II-induced pressor response with an ED50 value of 0.8 µmol/kg iv and 3.6 µmol/kg po.
Sparsentan also shows efficacious and long acting in the big ET-1-induced pressor model.
Sparsentan causes a significant lowering of blood pressure at the lowest dose tested (10 µmol/kg/day) in spontaneously hypertensive rats.
| M.Wt | 592.76 | |
| Formula | C32H40N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CCCCC(N(CC1=CC=C(C2=C(S(NC3=NOC(C)=C3C)(=O)=O)C=CC=C2)C(COCC)=C1)C4=O)=NC54CCCC5 |
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1. Murugesan N, et al. J Med Chem. 2005 Jan 13;48(1):171-9.
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