Catalog No.: PC-23653Not For Human Use, Lab Use Only.
TRV027 TFA (TRV120027 TFA) is a potent, selective β-arrestin biased ligand of angiotensin II type 1 receptor (AT1R), competitively antagonizes angiotensin II-stimulated G protein signaling.
TRV027 TFA (TRV120027 TFA) is a potent, selective β-arrestin biased ligand of angiotensin II type 1 receptor (AT1R), competitively antagonizes angiotensin II-stimulated G protein signaling. TRV027 stimulates β-arrestin recruitment and activates several kinase pathways, including p42/44 mitogen-activated protein kinase, Src, and endothelial nitric-oxide synthase phosphorylation via β-arrestin coupling. TRV120027 increases cardiomyocyte contractility in vitro. TRV120027 reduces mean arterial pressure in rats.
Physicochemical Properties
M.Wt
1040.10
Formula
C45H68F3N13O
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
D-Alanine, N-methylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- TFA salt
