Catalog No.: PC-43019Not For Human Use, Lab Use Only.
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM.
Angiotensin (1-7) (Ang-(1-7)) is an active heptapeptide of the Renin-angiotensin system (RAS), inhibits purified canine angiotensin converting enzyme (ACE) activity with IC50 of 0.65 uM; augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide, abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2; evokes anti-arrhythmogenic effects in animal models, upregulates cardiac nitric oxide synthase in spontaneously hypertensive rats.
Physicochemical Properties
M.Wt
899.0048
Formula
C41H62N12O11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 30.2 mg/mL
Chemical Name/SMILES
1-7-Angiotensin II, 5-L-isoleucine-
References
1. Li P, et al. Hypertension. 1997 Jan;29(1 Pt 2):394-400.
2. Alzayadneh EM, et al. Cell Signal. 2014 Dec;26(12):3027-35.
3. Averill DB, et al. Circulation. 2003 Oct 28;108(17):2141-6.
4. Costa MA, et al. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1205-11.
