Chemical Structure : CGP-42112
CAS No.:
127060-75-7
CGP-42112
(CGP42112;CGP 42112;CGP-42112A;CGP42112A;CGP 42112A)
Catalog No. : PC-43020Not For Human Use, Lab Use Only.
CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-4302001
Biological Activity
CGP-42112 (CGP42112A) is a highly potent, selective Angiotensin-II subtype 2 receptor(AT2 receptor) agonist with Ki of 0.24 nM; significantly inhibits cGMP production from the basal value, also significantly inhibits TH-enzyme activity from the basal value in cultured porcine adrenal medullary cells; antagonizes Ang-II induced contractions in rabbit aortic rings with IC50 of 1.85 uM.
Physicochemical Properties
M.Wt
1052.185
Formula
C52H69N13O11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 350 mg/mL
Chemical Name/SMILES
L-Isoleucine, N-(3-pyridinylcarbonyl)-L-tyrosyl-N6-[N2-[(phenylmethoxy)carbonyl]-L-arginyl]-L-lysyl-L-histidyl-L-prolyl-
References
1. Hakam AC, et al. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1430-6.
2. Takekoshi K, et al. Biochem Biophys Res Commun. 2000 Jun 7;272(2):544-50.
3. Näveri L, et al. J Cereb Blood Flow Metab. 1994 Jan;14(1):38-44.
4. Näveri L, et al. Acta Physiol Scand Suppl. 1995;630:1-48.
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