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A 834735

Chemical Structure : A 834735

CAS No.: 895155-57-4

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A 834735 (A-834735;A834735)

Catalog No.: PC-60764Not For Human Use, Lab Use Only.

A 834735 is a potent, nonselective, brain penetrant, full agonist at both the central CB1 and peripheral CB2 receptors with Ki of 4.6 and 0.31 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    A 834735 is a potent, nonselective, brain penetrant, full agonist at both the central CB1 and peripheral CB2 receptors with Ki of 4.6 and 0.31 nM, respectively.
    A 834735 reverses thermal hyperalgesia without adverse side effects in a rat neuropathic pain model.

    Physicochemical Properties

    M.Wt 339.5
    Formula C22H29NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [1-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone

    References

    1. Chin CL, et al. Br J Pharmacol. 2008 Jan;153(2):367-79.

    2. Grim TW, et al. J Pharmacol Exp Ther. 2016 Nov;359(2):329-339.

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