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AA-CW236

Chemical Structure : AA-CW236

CAS No.: 1869921-96-9

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AA-CW236 (AA-CW-236;AA-CW 236)

Catalog No.: PC-61160Not For Human Use, Lab Use Only.

AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
    AA-CW236 exhibits a high degree of selectivity towards MGMT.
    AA-CW236 strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.

    Physicochemical Properties

    M.Wt 400.786
    Formula C17H16ClF3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(5-(chloromethyl)-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-1-yl)ethyl)-3,5-dimethylisoxazole

    References

    1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5.

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