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Chemical Structure : AA-CW236
Catalog No.: PC-61160Not For Human Use, Lab Use Only.
AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
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AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency.
AA-CW236 exhibits a high degree of selectivity towards MGMT.
AA-CW236 strongly sensitizes the effect of DNA alkylating drug temozolomide in breast and colon cancer cells by fluorescence imaging and a cell-viability assay.
| M.Wt | 400.786 | |
| Formula | C17H16ClF3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang C, et al. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5.
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