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Chemical Structure : AA132
Catalog No.: PC-49720Not For Human Use, Lab Use Only.
AA132 (AA-132) is a small molecule activator of UPR signaling, covalently modifies a subset of ER protein disulfide isomerases (PDIs), activates global UPR signaling through a mechanism analogous to that of AA147.
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AA132 (AA-132) is a small molecule activator of UPR signaling, covalently modifies a subset of ER protein disulfide isomerases (PDIs), activates global UPR signaling through a mechanism analogous to that of AA147.
AA132 showed reduced selectivity for ATF6 transcriptional program activation in comparison to AA147, instead AA132 globally activates all three UPR signaling pathways.
AA132 covalently modifies PDIs to a greater extent than AA147.
AA132 globally activates the UPR through increased engagement of ER PDIs.
| M.Wt | 271.29 | |
| Formula | C16H14FNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gabriel M Kline, et al. bioRxiv. 2023 Jan 17;2023.01.16.524237.
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