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AA41612

Chemical Structure : AA41612

CAS No.: 433690-62-1

AA41612 (AA-41612)

Catalog No.: PC-62204Not For Human Use, Lab Use Only.

AA 41612 is a potent, synthetic melanopsin antagonist with IC50 of 15.8 nM, attenuates melanopsin photocurrent in a dose-dependent manner.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AA41612 is a selective and competitive OPN4 (melanopsin) antagonist with IC50 of 15.8 nM.
AA41612 attenuated melanopsin photocurrent in a dose-dependent manner, inhibited melanopsin photoresponses without inhibiting rod/cone function.
AA41612 reversibly attenuateed melanopsin-mediated photoresponses.

Physicochemical Properties

M.Wt 324.216
Formula C12H15Cl2NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[(2,5-Dichloro-4-methoxyphenyl)sulfonyl]piperidine

References

1. Jones KA, et al. Nat Chem Biol. 2013 Oct;9(10):630-5.

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