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AAA-10

Chemical Structure : AAA-10

CAS No.: 2758171-70-7

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AAA-10 (AAA10)

Catalog No.: PC-72714Not For Human Use, Lab Use Only.

AAA-10 (AAA10) is a second-generation gut-restricted pan-bile salt hydrolase (BSH) enzyme inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AAA-10 (AAA10) is a second-generation gut-restricted pan-bile salt hydrolase (BSH) enzyme inhibitor.
    AAA-10 inhibits BSH activity in mouse and human fecal slurry, bacterial cultures, and purified BSH proteins and displays reduced toxicity against mammalian cells.
    Oral administration of AAA-10 to wild-type mice for 5 days resulted in a decrease in the abundance of the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA) in the mouse GI tract with low systemic exposure of AAA-10.

    Physicochemical Properties

    M.Wt 472.656
    Formula C25H41FO5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3α,5β)-25-Fluoro-3-(sulfooxy)-26,27-dinorcholestan-24-one

    References

    1. Arijit A Adhikari, et al. ACS Chem Biol. 2021 Aug 20;16(8):1401-1412.

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