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Chemical Structure : AAA-10
Catalog No.: PC-72714Not For Human Use, Lab Use Only.
AAA-10 (AAA10) is a second-generation gut-restricted pan-bile salt hydrolase (BSH) enzyme inhibitor.
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AAA-10 (AAA10) is a second-generation gut-restricted pan-bile salt hydrolase (BSH) enzyme inhibitor.
AAA-10 inhibits BSH activity in mouse and human fecal slurry, bacterial cultures, and purified BSH proteins and displays reduced toxicity against mammalian cells.
Oral administration of AAA-10 to wild-type mice for 5 days resulted in a decrease in the abundance of the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA) in the mouse GI tract with low systemic exposure of AAA-10.
| M.Wt | 472.656 | |
| Formula | C25H41FO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arijit A Adhikari, et al. ACS Chem Biol. 2021 Aug 20;16(8):1401-1412.
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