AAL-149 | TRPM7 inhibitor | Probechem Biochemicals

Chemical Structure : AAL-149

AAL-149 (AAL149)

Catalog No.: PC-21131Not For Human Use, Lab Use Only.

AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.

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Biological Activity

AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.
AAL-149 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.

Physicochemical Properties

M.Wt	293.45
Formula	C18H31NO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-4-(4-(heptyloxy)phenyl)-2-methylbutan-1-ol

References

1/ Romero Rosales K, et al. Biochem J. 2011 Oct 15;439(2):299-311.

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AAL-149 (AAL149)

Biological Activity

Physicochemical Properties

References

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