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AAL-149

Chemical Structure : AAL-149

CAS No.: 177258-60-5

AAL-149 (AAL149)

Catalog No.: PC-21131Not For Human Use, Lab Use Only.

AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.

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    Biological Activity

    AAL-149 is a non-phosphorylatable FTY720 analogue and novel TRPM7 inhibitor, inhibits IM7 in a dose-dependent manner with IC50 of 1.081 uM, shows potent anti-inflammatory effects in vivo.
    AAL-149 inhibit LPS-induced inflammatory gene expression in macrophages and microglia.

    Physicochemical Properties

    M.Wt 293.45
    Formula C18H31NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (S)-2-amino-4-(4-(heptyloxy)phenyl)-2-methylbutan-1-ol

    References

    1/ Romero Rosales K, et al. Biochem J. 2011 Oct 15;439(2):299-311.

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