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Chemical Structure : AB928
CAS No.: 2239273-34-6
Catalog No.: PC-35841Not For Human Use, Lab Use Only.
Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.
AB928 displays high selectivity towards related receptors (A1R, A3R, CD73, CD39, NTPDase 2/3).
AB928 is a potent inhibitor of NECA-mediated A2aR activation on cell lines, potently reverses adenosine-mediated CD8+ T cell suppression, potently inhibits cAMP-mediated pCREB activation in human leukocyte populations in whole blood.
AB928 inhibits tumor micro-environment adenosine generation and signaling for the treatment of cancer.
| M.Wt | 426.484 | |
| Formula | C23H22N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile |
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1, Seitz L, et al. Invest New Drugs. 2019 Aug;37(4):711-721.
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