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AB928

Chemical Structure : AB928

CAS No.: 2239273-34-6

AB928 (Etrumadenant;AB-928;AB 928)

Catalog No.: PC-35841Not For Human Use, Lab Use Only.

Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.

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Biological Activity

Etrumadenant (AB928) is a potent, dual antagonist of the A2aR and A2bR adenosine receptors with Kb of 1.5 and 2.0 nM, respectively.
AB928 displays high selectivity towards related receptors (A1R, A3R, CD73, CD39, NTPDase 2/3).
AB928 is a potent inhibitor of NECA-mediated A2aR activation on cell lines, potently reverses adenosine-mediated CD8+ T cell suppression, potently inhibits cAMP-mediated pCREB activation in human leukocyte populations in whole blood.
AB928 inhibits tumor micro-environment adenosine generation and signaling for the treatment of cancer.

 

Physicochemical Properties

M.Wt 426.484
Formula C23H22N8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(2-amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile

References

1, Seitz L, et al. Invest New Drugs. 2019 Aug;37(4):711-721.

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