ABC transporter modulator-2 | ABCC6 modulator

Chemical Structure : ABC transporter modulator-2

ABC transporter modulator-2 (ABCC6 modulator)

Catalog No.: PC-28077Not For Human Use, Lab Use Only.

ABC transporter modulator-2 is a potent positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6, ABCB4, and ABCA4 P1380L with EC50 of <1 uM.

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Biological Activity

ABC transporter modulator-2 is a potent positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6, ABCB4, and ABCA4 P1380L with EC50 of <1 uM.

Physicochemical Properties

M.Wt	464.42
Formula	C19H15F3N6O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5'-cyano-6-((4,6-dimethyl-2-(trifluoromethyl)pyrimidin-5-yl)oxy)-[2,3'-bipyridin]-5-yl)methanesulfonamide

References

1. Patent WO2025151724 A1 2025-07-17.

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