ABC transporter modulator-5

Chemical Structure : ABC transporter modulator-5

Catalog No.: PC-28080Not For Human Use, Lab Use Only.

ABC transporter modulator-5 is a potent, selective positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6 with EC50 of <1 uM, shows high selectivity over ABCB4, ABCA4 P1380L and ACBC2.

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Biological Activity

ABC transporter modulator-5 is a potent, selective positive functional modulator (PFM) of ATP-binding cassette (ABC) transporter ABCC6, upregulates the expression of wild-type ABCC6 with EC50 of <1 uM, shows high selectivity over ABCB4, ABCA4 P1380L and ACBC2.

Physicochemical Properties

M.Wt	425.32
Formula	C19H18Cl2N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-chloro-N-(1-(3-chloro-4-(methylsulfonyl)phenyl)ethyl)-1-methyl-1H-indole-2-carboxamide

References

1. Patent WO2025129023 A1.

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