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ABL127

Chemical Structure : ABL127

CAS No.: 1073529-41-5

ABL127 (AB L127, ML174)

Catalog No.: PC-63266Not For Human Use, Lab Use Only.

ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM.

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Biological Activity

ABL127 (ML174) is a potent, selective, covalent inhibitor of protein methylesterase 1 (PME-1) with IC50 of 10 nM.
ABL127 (ML174) shows IC50s of 6.4 nM and 4.2 nM in HEK293T and MDA-MB-231 cells, respectively, decreases cell proliferation and invasive growth in vitro.
ABL127 (ML174) shows selectivity at 1 uM against 30 serine hydrolase anti-targets.
ABL127 (ML174) is highly active against PME-1 and can cause 85% reduction of demethylated PP2A, demonstrates greater potential for use in long time-course in situ studies.

Physicochemical Properties

M.Wt 332.356
Formula C17H20N2O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate

References

1. Pusey M, et al. Tumour Biol. 2016 Sep;37(9):11835-11842.

2. Bachovchin DA, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6.

3. Bachovchin DA, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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