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ABT-724

Chemical Structure : ABT-724

CAS No.: 70006-24-5

ABT-724 (ABT 724;ABT724)

Catalog No.: PC-70061Not For Human Use, Lab Use Only.

A potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ABT-724 is a potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.
ABT-724 elicits penile erections in rats at a dose of 0.03 uMl/kg, increases intracavernosal pressure in awake freely moving rats.

Physicochemical Properties

M.Wt 293.366
Formula C17H19N5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((4-(pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole

References

1. Brioni JD, et al. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.

2. Cowart M, et al. J Med Chem. 2004 Jul 15;47(15):3853-64.

3. Yin P, et al. Neurosci Lett. 2014 Sep 19;580:142-6.

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