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ABT-724 trihydrochloride

Chemical Structure : ABT-724 trihydrochloride

CAS No.: 587870-77-7

ABT-724 trihydrochloride (ABT 724;ABT724)

Catalog No.: PC-70062Not For Human Use, Lab Use Only.

ABT-724 trihydrochloride is a potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.

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Biological Activity

ABT-724 trihydrochloride is a potent, selective dopamine D4 receptor agonist that activates human dopamine D4 receptors with EC50 of 12.4 nM, with no effect on dopamine D1, D2, D3, or D5 receptors.
ABT-724 elicits penile erections in rats at a dose of 0.03 uM/kg, increases intracavernosal pressure in awake freely moving rats.

Physicochemical Properties

M.Wt 402.75
Formula C17H19N5.3HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1H-Benzimidazole, 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-, trihydrochloride (9CI)

References

1. Brioni JD, et al. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63.

2. Cowart M, et al. J Med Chem. 2004 Jul 15;47(15):3853-64.

3. Yin P, et al. Neurosci Lett. 2014 Sep 19;580:142-6.

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